Typography weighted at the bottom seems to aid dyslexics in keeping letters from dancing around. In the words of FastCoDesign.com:
it took a dyslexic designer to create a typeface that optimizes the reading experience for people who suffer from that condition.Christian Boer's "Dyslexie" doesn't exactly make the letterforms look conventionally beautiful, but since when is that a prerequisite for well-designed? If it works, it works.